MADIT

Multicenter Automatic Defibrillator Implantation Trial

 

Hypothesis:

To study whether, in patients with a previous MI and LV dysfunction, prophylactic therapy with an ICD can improve survival versus treatment with conventional medical therapy (e.g., amiodarone, beta-blockers/sotalol and class I antiarrhythmics)

Primary endpoint:

• Total mortality

Secondary endpoints:

• Arrhythmic mortality
• Costs and cost effectiveness

Status:

Start: December, 1990
Completion: March, 1996
Sample size: 196 patients
Published: New England Journal of Medicine, 1996

Results:

In post-MI patients at a high risk for VT, prophylactic therapy with an ICD reduced overall mortality by 54% and arrhythmic mortality by 75% compared with conventional medical therapy after a mean follow-up of 27 months.